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Post by fractal1 on Apr 24, 2009 4:39:56 GMT -5
That' a hard one Allison. I am erring on the side of no. E is lowish on day three, but it has managed to go up quite a way on day 21. Your cycle is also pretty regular from what I understand? I'd expect things to be going a bit haywire. LH and FSH seem to be peaking okay, with LH perhaps a little low. Low DHEA and T are more likely because the adrenals aren't working. I expected IGF-1 to be lower than that because of suppressive effect of cort :-? . Your symptoms including pre-HC suggests you have either low/inadequate GH feedback or low/inadequate aldosterone feedback. Looking at your IGF-1... it not too bad BUT aldosterone and sodium is in the dirt. I'm not sure about ADH except what I said in PM. It does look crap - but I just don't know. I'd also suggest taking progesterone because it's not fantastic.
I hope this helps a bit. Sorry, I wish I could be more helpful :-(
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Post by sallycinnamon on Apr 24, 2009 17:06:26 GMT -5
that's ok.....just need to find a doc who can confirm things for me :/ ugh!!! why would my GH be so low? mum had the exact same result and she's 67! thanks
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Dana
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Post by Dana on Apr 24, 2009 17:48:06 GMT -5
Hey Allison,
Were you fluid restricted when you had the vasopressin (ADH) checked? If not, then I'm not really sure you can compare those labs to anything.
If you were drinking water before the test, then your body would naturally cut down on ADH production. I think ADH are one of those tests where you need to be on at least a 12 hour fluid restriction to get a good idea. People with full blown diabetes insipidus, won't even be able to go without fluids for 12 hours...They would be in serious trouble probably within 4-5 hours, so just trying to restrict water a few hours is a good start. Don't go overboard or get yourself in trouble though. That's the reason water deprivation tests are done in a hospital, where someone is constantly watching and weighing you to make sure you aren't getting too dehydrated. I'm still not sure I even have DI. heh It might JUST be low aldosterone, which wasn't checked at the time.
Along with ADH, you should also check urine osmolality or specific gravity. They aren't the same thing, but pretty similar. Measuring that is more accurate than ADH from what I've researched. Once again, both of these should be checked when restricting all fluids. My modified water deprivation test, showed that I was borderline DI. Part of me just thinks it's low aldosterone.
As for your IGF -1. It looks like they checked IGF binding protein-1 rather than the actual IGF-1. The lab ranges on IGF-1 is usually something like 120-350. The first lab did this same exact thing to me! As for the GH, I'm 25 years old and mine was 0.7 so I'm not sure how to what to make of your results based on that.
I agree with Ruth that your aldosterone looks terrible.
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Post by sallycinnamon on Apr 24, 2009 23:04:55 GMT -5
Hi Dana, No I wasn't fluid restricted, I had about 200ml of water before the test so my veins would hopefully co-operate (they didn't!!). I'm going to see if I can get the additional testing done, as the ADH looks so low and I pee on average every hour. If I don't take sea salt at night, I would pee 4-5 times or more. Florinef didn't resolve this issue for me. I'm able to restrict water overnight, say for 9 hours. I also don't get that thirsty in general, but I've read that that isn't a symptom that 100% of people with DI get. All so confusing this stuff isn't it! Now I just need to find a doc to get me tested properly! thanks again
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Post by fractal1 on Apr 24, 2009 23:25:52 GMT -5
Dana - Thanks for the info on DI. The units for IGF-1 are Aussie, so they're very different. Unfortunately, GH fluctuates quite a bit and really is a good for nothing measure. Allison - The fact that sodium helps rules out ADH deficiency , unless you have multiple hormone deficiencies, which are clouding interpretation. Low ADH results in a loss of H2O and sodium goes through the roof. Also, your pee should be clear. I'm really thinking you should try a pred/florinef combo. You shouldn't need that much HC. Then, if you're still having dramas, I would retest. Hope you're having a good Anzac weekend
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Dana
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Post by Dana on Apr 26, 2009 13:05:10 GMT -5
Hi Dana, No I wasn't fluid restricted, I had about 200ml of water before the test so my veins would hopefully co-operate (they didn't!!). I'm going to see if I can get the additional testing done, as the ADH looks so low and I pee on average every hour. If I don't take sea salt at night, I would pee 4-5 times or more. Florinef didn't resolve this issue for me. I'm able to restrict water overnight, say for 9 hours. I also don't get that thirsty in general, but I've read that that isn't a symptom that 100% of people with DI get. All so confusing this stuff isn't it! Now I just need to find a doc to get me tested properly! thanks again Yes all of this is very confusing! I agree. To give you an idea after 12 hour water deprivation my ADH was 2.3 (1-13.3) and that was borderline. It's very difficult finding information on this and most of the information out there is with urine osmolality. Unfortunately when I had my test done, the stupid hospital didn't order the right urine tests and that data was lost. If your urine looks like water, then I'd definitely try to find a doc who will do a formal water deprivation test with you.
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Post by justaustin on Apr 26, 2009 13:36:30 GMT -5
So, in theory.. with water deprivation...it should drive ADH up. To further prevent water loss? Am I right? Like salt restriction allows aldo to rise.
I think we could use a sticky or table about ADH... Thoughts?
Laurie
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Post by sallycinnamon on Apr 26, 2009 22:43:58 GMT -5
Yep that's the idea. If you're not drinking enough water, ADH rises so the body can hold on to the water that is there.
I've booked in to see an endo (gulp) on 19th May. Apparently she's very approachable so fingers crossed. Not seeing my regular hormone doc as she's frighteningly expensive and apparently not good with Pit problems. The other doc I've been seeing didn't even want to test my pit hormones!! argh!
I think a sticky would be GREAT because I bet there are others out there who pee excessively and Florinef doesn't resolve it. It seems like ADH doesn't get thought of much.
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