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Post by sallycinnamon on Apr 10, 2009 20:54:34 GMT -5
I've thought about switching to all-pred but I don't seem to get any obvious low cortisol symptoms. I don't seem to be watching the clock for my next dose or feel desperate to take it in the morning. It has definitely helped me though, so I'm sure I need some form of cortisol. I take the 1mg pred at bedtime just so I have some decent overnight cortisol coverage. How would I go about swapping and how would I know it's benefitting me (apart from if I start feeling better)? Not sure what new doctor thinks about pred, will have to ask him as I don't want to start taking it then be left with no source! Though there is a backup option in place I definitely feel more energy since going back to regular DHEA, I'll be sticking with 50mg for a few more weeks and then either drop back to 25mg or stay on 50mg. When I was previously on 25mg regular DHEA, my levels were only about 5 (2.0-11.0), so that suggests I might need a higher dose. I seem to tolerate it OK, no affect on sleep (I take it pretty early in the day). I also feel better on T3-only. Some of my symptoms seem to have disappeared - eg. memory problems, word-finding problems. I'm almost up to the 12 week mark so will need to work out what to do after that. I've definitely got conversion problems (high RT3/FT3 ratio) so I might stay on T3 only while I work on oestrogen dominance or do an NTH/T3 combo. I've picked up a bug though, so I feel like shite at the moment...can't wait til the day my immune system is stronger. Thanks again, I'll post the rest of the results when they come in. Hope you're enjoying the long weekend!
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Post by sallycinnamon on Apr 12, 2009 3:06:33 GMT -5
Me again! Do you happen to know what a good ratio for E2/progesterone should be in the follicular phase? I know in luteal, my doc said 6:1 oestradiol/progesterone but I have no idea for follicular. thanks
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Post by fractal1 on Apr 12, 2009 22:03:12 GMT -5
"Do you happen to know what a good ratio for E2/progesterone should be in the follicular phase?" I don't think there is one... if you want to look at the ratios, it's better to get the blood drawn on day 21. btw I'm trying to put together some information on optimizing sex hormones and have been scrawling all over the internet looking for some good resources... but I'm not finding much at all , so if you have any gems of knowledge please let me know:). "I've thought about switching to all-pred but I don't seem to get any obvious low cortisol symptoms. I don't seem to be watching the clock for my next dose or feel desperate to take it in the morning. It has definitely helped me though, so I'm sure I need some form of cortisol. I take the 1mg pred at bedtime just so I have some decent overnight cortisol coverage." The fact that you need pred at night suggest that you are still metabolizing HC relatively quickly. I would switch to all-pred really slow, perhaps by 1/4 tab (1.25mg) at a time, and keeping in mind that it takes a little longer for it to enter you system. "Though there is a backup option in place "...ah, that would happen to be D. Mule ;D ;D "I've definitely got conversion problems (high RT3/FT3 ratio) so I might stay on T3 only while I work on oestrogen dominance or do an NTH/T3 combo."I would do the NTH/T3 combo. Ignoring high cortisol dose, I'm highly suspect of low 'baseline' levels of growth hormone. I would also consider trying a GH secretagogue.
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Post by fractal1 on Apr 12, 2009 22:08:19 GMT -5
"Do you happen to know what a good ratio for E2/progesterone should be in the follicular phase?" I don't think there is one... if you want to look at the ratios, it's better to get the blood drawn on day 21. btw I'm trying to put together some information on optimizing sex hormones and have been scrawling all over the internet looking for some good resources... but I'm not finding much at all , so if you have any gems of knowledge please let me know:). "I've thought about switching to all-pred but I don't seem to get any obvious low cortisol symptoms. I don't seem to be watching the clock for my next dose or feel desperate to take it in the morning. It has definitely helped me though, so I'm sure I need some form of cortisol. I take the 1mg pred at bedtime just so I have some decent overnight cortisol coverage." The fact that you need pred at night suggest that you are still metabolizing HC relatively quickly. I would switch to all-pred really slow, perhaps by 1/4 tab (1.25mg) at a time, and keeping in mind that it takes a little longer for it to enter you system. "Though there is a backup option in place "...ah, that would happen to be Dr. Mule!!?? ;D ;D "I've definitely got conversion problems (high RT3/FT3 ratio) so I might stay on T3 only while I work on oestrogen dominance or do an NTH/T3 combo."I would do the NTH/T3 combo. Ignoring high cortisol dose, I'm highly suspect of low 'baseline' levels of growth hormone. I would consider trying a GH secretagogue. [a href="http://[del:fractal1]"]http://[del:fractal1][/a]
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Post by fractal1 on Apr 12, 2009 22:10:26 GMT -5
DARN! Cinnamon girl.. I hate it when I quote myself
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Post by sallycinnamon on Apr 13, 2009 6:04:22 GMT -5
Habo! What sort of info re optimizing are you looking for? A site that I quite like, although I don't agree with everything I read on it is www.womentowomen.com - it makes the information a lot easier to digest and has lots of good articles. Unfortunately, it doesn't mention HC and also doesn't refer to hypoPit as far as I can see so some of the statements are misleading in a way (for example, saying that people can come off DHEA after a while once adrenals recover). The pred at night was more an experiment - it hasn't really benefitted or made much difference. I decided it would be a good idea to have some overnight cortisol coverage and I didn't like the idea of taking HC which would burn up pretty quick and maybe make me wake up. Interestingly, I was stress dosing for about 5 days due to a bad cold (totalling between 50-60mg/day) and I've now dropped back to 33mg with no problems. No low cortisol symptoms. Started Progest-e again and it seems to be working. I slept SO well last night and feel more positive. Hopefully it will last. I've had so much trouble trying to find info about E2/prog ratio so I gave up, I'll just rely on what doc told me about Day 21 ratios. There was some info I found but it was more about saliva than serum.
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Post by fractal1 on Apr 13, 2009 22:26:04 GMT -5
Thanks for the site. I haven't had a good look yet, but I think it might provide some gems . I'm basically looking for some data on appropriate labs, BRHT dosing, and dosing regimes. For example, if someone was using 0.8ml 0.5% topical T - what is that equivalent too (i.e. other forms).. Is it within recommended dose etc. etc.? "Interestingly, I was stress dosing for about 5 days due to a bad cold (totalling between 50-60mg/day) and I've now dropped back to 33mg with no problems. No low cortisol symptoms."That's really great to hear.. probably helps that you slept well too
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Post by sallycinnamon on Apr 23, 2009 22:01:46 GMT -5
Hi guys,
Finally got all my results back. I've updated the first post with all the results. Vasopressin is terrible but it explains the excess peeing daytime and night time. I was wondering why Florinef didn't resolve that for me. HC and salt have helped but still not great.
What do you make of the growth hormone etc?
I'm thinking I must be hypoPit with many low pit hormones.
thanks Allison
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