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Post by k9gang on Jan 22, 2009 10:49:18 GMT -5
Thanks. I'm very familiar with that link. So basically Methylprednisolone has less mineralcorticoid potency and more glucocorticoid potency than PrednisoLone, and both have the same half lives. There seems to be very little difference between the two other than one is methylated. Methylprednisolone ended up making me feel worse. Elevated BP, more rapid heart beat, frequent irregular heart beat (2-3 times per week). On the days when I did not take it, I did not have any of those symptoms! PrednisoLone seems to work well for me at this time. I feel great. Heart rate and BP are normal 'for me', irregular heart beat "only" when I forget to address sodium/potassium for the day which is rare. So why why why is one poison to me and the other a godsend? This is what I am trying to figure out.
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Post by Lethal Lee on Jan 22, 2009 23:02:04 GMT -5
Hi Sam,
Glad to read that the Prednisolone is working well for you. It does for me too.
Over the past year I have been on 7.5-10mg Prednisolone.
I cant comment on Medrol as it is not available in Australia at all so I have never tried it.
As to why one works well for you and another doesnt no-one can really say. Of course many meds are the same some just work better for different individuals. For example for A.D.D. meds Ritalin does NOTHING for me while Dexamphatamine is an absolute marvel. Yet both supposedly work the same .... by raising Dopamine.
Docs just call this individual variability.
I suspect it has a lot to do with Liver Function & other things like Toxin load, nutritional hormonal & enzyme deficiencies & imbalances.
Someone mentioned problems with methylation I have Mercury Toxicity which does affect methylation (Suphur pathways). Possibly its a factor for you too? Anyway I'm glad I didnt try Medrol maybe it would have been "poison" to me too.
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Post by k9gang on Jan 23, 2009 1:07:50 GMT -5
Not mercury toxic...nor iodine deficient anymore. Liver is healthy. Thyroidless but on full replacement with Armour Thyroid (non-symptomatic), ovaryless but optimized on transdermal BHRT. Only issue has been getting the right Rx to address hypo-pit. Sulfur pathways? I looked up methylation. "In biochemistry, methylation more specifically refers to the replacement of a hydrogen atom with the methyl group." I looked up the methyl group: science.jrank.org/pages/4286/Methyl-Group.html Hmmm...
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Post by Lethal Lee on Jan 23, 2009 2:50:27 GMT -5
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Post by k9gang on Jan 23, 2009 13:56:06 GMT -5
Thanks for that link. No more methylated prednisolone for me...
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