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Post by mamabear on Feb 13, 2009 15:59:52 GMT -5
Hey guys! Its MamaBear from RTH; Chris, I hope life has been treating you well over here! I have a question for you, realizing that you don't like 24 hour collection testing for total production, but that's where we started. My current dosing schedule is thus: 150 mcg T3 30 mg HC .1 Florinef My total GH production for a day- 8091 pg/24 hour(1065-4722) Testosterone was very low at 1.8 (5.0-35.0) ug/24 hour I'm confused! I can NOT lose weight-low carb, low fat, grain free, you name, the ol' scale just KEEPS on a climbin', excercise tolerance is low, no muscle definition minor facial hair-I have more dark hairs ;D but they are finer than pre-HC. Any thoughts? Where should we go from here? Thanks!
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Post by fractal1 on Feb 14, 2009 15:27:16 GMT -5
Hi Laurel, There are a number of causes of elevated urine GH. Some of these include: - Acromegaly (Gigantism) - Pregnancy, 1st & 3rd trimester - Diabetes mellitus - Hemochromatosis - Renal failure A few questions that might help narrow things down:- Can you give me the results of everything else that tested at the same time as urine GH. - Was serum GH tested at the same time as urine GH? Other recent labs of special interest include:- fasting glucose & insulin - iron & ferritn - creatinine - cholesterol - sex hormones Cheers
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Post by mamabear on Feb 16, 2009 12:11:17 GMT -5
Yikes. Well, Ruth, here's what I have so far. Thanks for your help! How's life on the warm side of the planet?
3 hour Post Prandial glucose 142 taken yesterday 10 hour fasting glucose 117 taken this am ug/24 hr Estrone 6.5 (3.3-44.6) 8% of range Estradiol 3.4 (1.4-12.2) 19% of range Estrial 14.6 (6.1-32.4) 32% of range
Total Estrogen 24.5 (10.8-89.2) 17% of range Estrogen quotient 1.5 (estriol/(estrone+estradiol) (>1.0)
2-OH Estrone 5.7 (3.8-38.1) 6% of range 16a-OH Estrone 6.5 (2.1-7.9) 2/16a ratio .9 (1.8-5.5) LOW
4-OH Estrone 2.3 (0.8-5.9) 2-Methoxyestrone 2.0 (2.2-14.4) LOW 2-Methoxyestradiol .4 (.1-2.2) 14% of range Pregnanediol 2334 (1450-6140) 19% of range
DHEA 316 (100-2000)11% of range Testosterone 1.8 (5.0-35.0) LOW
5a-Androstanediol 15.4 (3.0-35.0) 5B-Androstanediol 16.7 (13.0-180) 2% of range Androsterone 1643 (500-3200) Etiocholanolone 777 (500-5000) 6% of range Pregnanetriol 1769 (100-1500) HIGH Cortisone (E) 116 (31-209) Cortisol (F) 95 (30-170) Tetrahydrocortisone 6774 (1700-4200) HIGH Allo-Tetrahydrocortisol 3086 (400-2100) HIGH Tetrahydrocortisol 2695 (900-2600) HIGH 11B-Hydroxyandrosterone 859 (398-1471) 11B-Hydroxyetiocholanolone 682 (153-827) Aldosterone 3.6 (6.0-25.0 Normal diet. 0.0-6.0 High Salt)
Allo-Tetrahydrocorticosterone 193 (130-600) 13% of range Tetrahydrocorticosterone 52 (30-240) 10% of range 11-Dehydrotetrahydrocorticosterone 128 (62-293)
pg/24hour Human Growth Hormone 8091 (1065-4722) HIGH
ng/24 hour Free T3 2481 (470-1750) HIGH on 150 mcg Cytomel daily Free T4 86 (430-3200) LOW
nmol/24hour Sodium 89 (40-220) Potassium 34 (25-150) Sodium/Potassium ratio 2.6 (1.2-4.8)
NO FSH/LH, IGF-1.
Looks as though high growth hormone causes insulin resistance and subsequent type II diabetes; which is near where I am per blood glucose.
The really weird part For several weeks I felt like I just couldn't get enough HC. Needed roughly 45 mgs a day. Then, all of the sudden-I stopped needing HC. Am now taking between 15 and 20 mgs a day as needed, because I don't need it, and too much makes me too warm.
I'm having an appt as soon as I can with Dr. M but am really confused as to just what is going on!
Thanks!
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Post by fractal1 on Feb 17, 2009 4:12:41 GMT -5
Hi Laurel, I've done a lot of reading, but have hit a brick wall; because you are on cortisol and thyroid replacement, interpreting labs results just isn't that clear cut. Some results support one thing while others suggest differently. My inkling is diabetes BUT I really can't be sure. Serum GH, IGF-1 and electrolytes would've been really helpful . I did find a paper where you could determine diabetes from the ratio of particular urine corisones & cortisols; but unfortunately, I don't have access to it. I'm guessing Dr. M. know this, since he ordered those tests specifically. So, my advice is: Get your butt down to Dr. M. as soon as you can so you can get this worked out ;D I'm really sorry I couldn't be more help. Cheers
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Post by mamabear on Feb 17, 2009 13:59:29 GMT -5
I'm a step ahead of you! Going to have a chat tomorrow. Thanks for taking a look-I will let you know what he says so you know...for future reference. Leave it to me to be confusing ;D My blood sugar is considerably higher than what it has been in the past-I expect I'm probably looking at type II diabetes until I get a handle on the growth hormone-I just have to figure out why, and maybe the growth hormone is it, and whether the chicken or the egg came first. Thanks!
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Post by fractal1 on Feb 17, 2009 14:26:05 GMT -5
That's great!! Yes, please let us know! I think you can't figure out the 'chicken or the egg' thing because no one really knows. I've read some articles saying a derangement in GH secretion results in diabetes in juveniles, but others saying that it's the high blood sugar. Good luck
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Post by mamabear on Feb 18, 2009 14:37:11 GMT -5
Alright, M'dear. Here's the scoop. Not a big deal. Should come down once I'm on enough thyroid. Apparently 150 mcg of Cytomel isn't enough. So. Adding armour cream, plus a testosterone/estriol/T3 cream as well. He said it's usually high in people who aren't taking in enough calories, but since I gain weight if I take in MORE calories than what I do (oh the joys of a tortesian metabolism!), it's obvious things aren't firing properly. Thinks the T cream will rearrange things a bit. Here's hoping. That's a much better answer than diabetes or acromegaly (which, granted, aren't completely ruled out, but looking less and less likely.) Thanks for your help Fractal! Have a great afternoon Breathing several big sighs of relief- Laurel
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Post by fractal1 on Feb 19, 2009 15:58:20 GMT -5
That's great to hear!! ;D So he thinks it's insulin resistance due to low thyroid? If you're taking T3-only, it means you don't have much T4 reserves - so taking a higher dose would make sense. It can't be good to be on T3-only for too long . Are you taking T3-only to clear RT3? Cheers
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